The role of catecholamines, melatonin and nitric oxide in the mechanisms of stress damage to the body

The mechanisms of response and adaptation the body's regulatory systems to stress factors is an urgent fundamental task goal this study. study used four experimental models stress: acute stress, chronic their sequences. An was induced in a 60-minute forced swimming test model pool. Chronic simulated by restricting mobility (hypokinesia), which done placing rats into special AE1001-R1 rat retainers, made transparent polypropylene (OOO OpenScience, Russia), they were kept for 10 days, 20 hours day. levels biogenic amines (adrenaline, norepinephrine, serotonin), melatonin nitric oxide blood serum determined method enzyme-linked immunosorbent. results obtained provide fair evidence increased functional activity both stress-response (sympathoadrenal system) stress-limiting (ST, MT, NO) reactions body, severity depends on duration sequence stimuli animals.